What is Zopiclone?
Sold under the brand name of Imovane, Zopiclone is a nonbenzodiazepine used in the treatment of insomnia. Nonbenzodiazepines are a class of pharmaceutical drugs with a different chemical structure from benzodiazepine but exhibit the same sedative properties. Of the nonbenzodiazepines, Zopiclone, because of its hypnotic properties, is classified as a cyclopyrrolone and used worldwide because of its efficacy.
What are the uses of Zopiclone?
Zopiclone is useful in relieving bad bouts of insomnia that do not respond satisfactorily to other medications. It helps you fall asleep quickly by reducing the interrupting waking hours in between sleep. Along with this use, research has shown that Zopiclone is effective in shift work sleep disorder cases that occur in people with irregular work schedules, especially night-time.
How does Zopiclone work?
GABA or Gamma-Aminobutyric Acid is an inhibitory neurotransmitter responsible for regulating nerve impulses. GABA induces sleepiness, relaxes muscles, and reduces anxiety in a person. Research has shown that GABA levels are reduced by almost 30% in people with chronic primary insomnia. Zopiclone binds to the GABA receptors but at a different site from pure Benzos to increase the GABA activity. This results in activating their sedative effect and uninterrupted sleep of 7-8 hours.
Can I use Zopiclone for anxiety?
Studies have shown that Zopiclone can be used as an effective treatment option for anxiety. Zopiclone users showed improvements in a study comparing four weeks of treatment with Zopiclone 7.5 mg, Triazolam 0.5mg, and placebo in patients with generalized anxiety disorder. The Hamilton Anxiety Scale showed a lesser anxiety scale of 18.2 in Zopiclone compared to the 22.4 scores in Triazolam.
What is the strength and Dosage of Zopiclone?
Zopiclone is available in strengths of 3.75 mg and 7.5 mg. The required dosage of Zopiclone depends on your age, the severity of your condition, and the medical practitioner’s advice. Adults over 18 are advised for 7.5 mg Zopiclone before bedtime for its sedative effects. But if the severity of insomnia is less, lower doses can also be used. In older adults above 65 years or in the case of patients with low metabolic rates, 3.5 mg Zopiclone is the ideal dose.
How long does Zopiclone take to work?
Zopiclone has a bioavailability of 75-80% and gets rapidly absorbed by the system after ingestion. It takes 1-2 hours for the plasma concentration to peak in the system. The Zopiclone half-life is about 3.5 – 6.5 hours. It does not stay in the body for more than 12 hours. But sometimes its lingering effects have been observed because you should be careful driving or using heavy machinery after using it. After 12 hours, it gets metabolized by the liver and eliminated through the kidneys in the form of urine and feces.
Where to buy Zopiclone online in Australia?
Zopiclone Australia, being a prescription medication, can be obtained from pharmacies using the prescription. But you can also buy Zopiclone online. However, before ordering from any e-pharmacy, check its Zopiclone reviews and site registration to rest assured of its authenticity. After delivery, check for the condition of the package and signs of tampering, if any. If the tablets look yellowed or soggy, discard them.
What are the things to remember while taking Zopiclone?
Zopiclone is a short-term medication for the treatment of insomnia. Its use should not be extended long term as it will increase Zopiclone withdrawal symptoms. It should not be crushed or broken but swallowed whole. That’s because crushing causes abnormal quantities of the drug to accumulate in the bloodstream. Do not take a second dose if you wake up at night after one dose. Additionally, do not abruptly stop the medication but taper its use for minimum adverse reactions.
Is Zopiclone addictive?
Zopiclone is designed to be used on a short-term basis. You will not get addicted to it if you use it for a few weeks. But long term use of the medication can lead to dependence on the medication. This, in turn, can increase the intensity of the withdrawal effects. People with an alcoholism history are more at risk of Zopiclone addiction. But those with poor metabolic rates should be careful as it makes the effects of the medication last longer in the body.
What are some common Zopiclone side effects?
A bitter or metallic taste in the mouth, dry mouth and lingering feeling of lethargy are some of the common side effects associated with the use of Zopiclone. Sometimes nausea, headache, dizziness, and vomiting occur with its use. Nightmares and a feeling of agitation have also been recorded in long-term users of Zopiclone. Rarely, the user may experience a variety of mood swings in the form of confusion, aggression, and hostile behavior. It is also normal to experience temporary memory loss, hallucinations, with respiratory depression. If such things happen, discontinue the medication and get prompt medical help for your condition.
What are the contraindications of Zopiclone?
Zopiclone safety is still under research in the case of children and adolescents under 18 years of age. That’s why it should be strictly used only for adults. It is also avoided in people with sleep apnea which causes breathing to stop while sleeping temporarily. Patients with severe breathing problems and conditions of myasthenia gravis are contraindicated from taking the medication. It is also avoided in patients with hepatic impairments since the medication is metabolized in the liver. Additionally, people with hypersensitivity to the drug or those severely allergic to the ingredients in the drug should not use Zopiclone in the first place.
What are the drug interactions of Zopiclone Australia?
Zopiclone with Opioids
Zopiclone with Opioids, like morphine and Tramadol, can lead to severe sedation effects. These effects may cause such deep sleep that you may feel trouble breathing properly during your sleep or need help after waking up.
Zopiclone with Painkillers
Painkillers like co-codamol, codeine, or dihydrocodeine further increase the sedation effects of the body when combined with Zopiclone.
Zopiclone with Antibiotics and Antifungal drugs
Antibiotics and Antifungal medicines increase the amount of Zopiclone in the blood leading to overdose symptoms.
Can I take Diazepam and Zopiclone at the same time?
Zopiclone 7.5 mg and Diazepam do not interact and can be safely used without any issue. But sometimes, side effects can occur, especially in people with other systemic conditions. It is important to take these two medicines under your doctor’s supervision.